Functional ion channel activity can be hindered by prolonged exposure to drugs that inhibit trafficking of the channel protein from cytoplasmic sites to the surface membrane.
HERG-Lite® and CHAN-Lite® are chemiluminescent assays that identify trafficking inhibition in cardiac cell lines following overnight drug exposure.
- Determine specificity of drug-induced trafficking inhibition
- Identify compounds that enhance cell-surface expression
- Rapid results