Overview
Charles River offers a wide range of orthogonal platforms for primary screening, fragment screening, hit confirmation and characterization, hit-to-lead and lead optimization.
Targets are addressed individually, and the most efficient and pharmacologically relevant solution is provided.
| Surface Plasmon Resonance (SPR) |
- Biacore 4000 for high-throughput hit identification
- Biacore T200 with added sensitivity for kinetic profiling, mechanistic analysis and backup screening
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| High-Concentration Biochemical Assays |
- Multi-modal fluorescence and luminescence readouts
- Electrophoretic mobility (Caliper)
- Binding assays and other high-concentration biochemical assays
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| X-ray Crystallographic Screening |
- In-house X-ray facility with synchrotron access
- Crystal bank of structures
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| Native Mass Spectrometry |
- Label-free technology for detecting protein-ligand complexes in their native state
- Highly sensitive and information rich (binding mode, affinity and stoichiometry)
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