Structural Biology Services Improve Potency and Selectivity

Improving chemical matter during the lead optimization stage is critical to an efficient drug discovery project. Structural biology and biology protein structure services decipher the structure-function relationship of biological macromolecules.

Once the structure-function relationship has been defined, you can make changes to the ligands to improve potency and selectivity of your lead molecule.

Structural Biology Platforms and Techniques

We offer structure-based drug discovery services through gene to structure, including incorporation of your selected ligands. In addition, a range of biophysical techniques are available to accelerate and deepen the understanding of the interactions your ligand makes with its biological target, such as:

  • Construct design and cloning
    • Facilitated by computer-aided design with all targets considered, complemented with antibody generation and optimization
  • Cryogenic electron microscopy (Cryo-EM)
    • Services provided in collaboration with our partner and industry leader, ATEM 
    • ATEM's leading platform integrates biochemistry, hardware and software to provide in-depth structural insights about challenging targets at commercial scale
    • Provides a considered approach to solving structures which pose a challenge using NMR and X-ray crystallography, such as membrane and large multiple subunit proteins
    • Maintains protein in a biologically relevant environment
  • Protein expression and scale up
    • Escherichia coli, baculovirus and mammalian expression 
  • Protein purification and crystallization
    • High-throughput crystallization robotics
  • Biophysics - SPR (Surface Plasmon Resonance), Isothermal Calorimetry (ITC), Thermal Shift Assay (TSA)
    • From low to high throughput with binding and kinetic analysis in various formats: protein-small molecule, protein-protein, RNA-protein, and antibody-antigen
    • Fragment screening, offered with internal fragment libraries
  • X-ray Crystallography
    • Crystallization screening
    • Regular synchrotron collections (Diamond Light Source and other European synchrotrons)
  • Nuclear magnetic resonance (NMR)
    • Access to 600 MHz Bruker AV3 spectrometer equipped with QCI cryoprobe and sample changer
    • Fragment screening using 19F fragment library
    • Protein and ligand observed binding analysis

Our structural biology team offers a flexible approach to meet the needs of your discovery project. We offer both standalone structural or biophysical projects, and may also work as part of our comprehensive and drug design integrated teams, providing a seamless experience for our clients. We can provide unit-based milestones or full-time equivalent (FTE) services tailored to your specific timeline and budget.

Contact a Specialist