Biophysical Techniques in Drug Discovery

Charles River provides biophysical techniques using tailored high-quality biological reagents to accelerate and deepen the understanding of compound-target interactions.

Our techniques range from simple thermal shift assays to more advanced techniques, such as surface plasmon resonance (SPR) measurements (using Biacore™ instrumentation) that provide vital kinetic data on ligand binding to its target, and isothermal titration calorimetry (ITC) studies that generate important thermodynamic information about protein-ligand interactions.

We also have access to high-field NMR and mass spectrometry to further our expert analysis of mode of action studies and protein-protein or protein-ligand interactions.

Biophysical Analysis

  • Thermal shift assay
  • Mass spectrometry
  • Isothermal titration calorimetry
  • Surface plasmon resonance
  • NMR
  • Crystallography