Biophysical Techniques in Drug Discovery
Charles River provides biophysical techniques using tailored high-quality biological reagents to accelerate and deepen the understanding of compound-target interactions.
Our techniques range from simple thermal shift assays to more advanced techniques, such as surface plasmon resonance (SPR) measurements (using Biacore™ instrumentation) that provide vital kinetic data on ligand binding to its target, and isothermal titration calorimetry (ITC) studies that generate important thermodynamic information about protein-ligand interactions.
We also have access to high-field NMR and mass spectrometry to further our expert analysis of mode of action studies and protein-protein or protein-ligand interactions.
- Thermal shift assay
- Mass spectrometry
- Isothermal titration calorimetry
- Surface plasmon resonance