CIA Mouse & Rat Model Studies
Susceptibility to collagen-induced rheumatoid arthritis is strongly associated with major histocompatibility complex class II genes, and the development of the disease is accompanied by a robust T-cell and B-cell inflammation response to type II collagen.
The chief pathological features of collagen-induced arthritis include a proliferative synovitis with infiltration of polymorphonuclear and mononuclear cells, pannus formation, cartilage degradation, erosion of bone and fibrosis. As in human rheumatoid arthritis, pro-inflammatory cytokines (e.g., TNF-a, IL-1b and IL-6) are increased in collagen-induced arthritis. Biological therapies designed to interfere with these mediators are active in these models.
Disease activity is determined by measuring inflammation swelling in the affected joints (paw volume or thickness) over time. Treatments can be assessed in either prophylactic or therapeutic testing paradigms. Additional measures of disease activity include evaluation of C-reactive protein (CRP) and erythrocyte sedimentation rate.