Charles River scientists recently characterized the previously described the oxaliplatin mouse model’s response to cool allodynia, or pain in response to cooling, using two behavioral tests—the tail immersion/flick test and the acetone cooling test. Cool allodynia occurred during and after oxaliplatin infusion, and is thought to arise from a direct effect of oxaliplatin on peripheral sensory neurons. Review the key findings and select data below.
- Exposure to oxaliplatin led to persistent cool allodynia in the acetone test, which is a reliable method to test oxaliplatin-induced peripheral neuropathy.
- Treatment with nerve pain medications, pregabalin and duloxetine, alleviated the allodynia response.
- There was significant variation within each group (control and treated) in the tail immersion/flick test, suggesting that the tail immersion/flick test is not a reliable method to measure cool allodynia.