Anatomical/Structural MRI Studies

Anatomical or structural MRI is used to study the shape, volume, integrity, and developmental changes in brain tissues and blood brain barrier (BBB). Some of the applications for structural MRI include studying brain atrophy in neurodegenerative disease models and ischemia or hemmorhagia in stroke models.

At Charles River, our imaging team performs routine high-throughput measurement and longitudinal phenotyping studies. We also offer high resolution T2-weighted imaging. Ex vivo 3D anatomical imaging supports high resolution anatomical phenotyping and allows long scan times to maximize image resolution in complete 3D.

Anatomical MRI
Figure 1: Fast spin-echo sequence, 12 min scan, 18 x 0.7 µm slices, 78 mm in plane
Chart showing increased atrophy in the striatum and cortex of a Huntington’s disease homozygous mouse model compared to wildtype
Figure 2: Increased atrophy in the striatum of a Huntington’s disease homozygous mouse model compared to wildtype
Chart showing increased atrophy in the cortex of a Huntington’s disease homozygous mouse model compared to wildtype
Figure 3: Increased atrophy in the cortex of a Huntington’s disease homozygous mouse model compared to wildtype