EAE-induced Model of MS

This platform for multiple sclerosis (MS) focuses on induction of experimental allergic encephalomyelitis (EAE) in rats and mice.

EAE is induced via injection of an inoculum containing either myelin oligodendrocyte glycoprotein (MOG) or proteolipid protein (PLP). Available models include acute, progressive or relapsing-remitting disease course with elements of inflammation and neurodegeneration, components relevant to human MS.

  • STUDY PARADIGM
    Example study paradigm using an EAE-induced model of MS

    Example study paradigm using an EAE-induced model of MS

  • VALIDATION DATA
    Clinical Score of MOG-induced EAE in mice (Treatment with Vehicle or Copaxone)

    Clinical Score of MOG-induced EAE in mice
    (Treatment with Vehicle or Copaxone)


    TNF-α measured in brain in MOG-induced EAE in mice

    TNF-α measured in brain in MOG-induced EAE in mice


    TNF-α measured in spinal cord in MOG-induced EAE in mice

    TNF-α measured in spinal cord in MOG-induced EAE in mice