The corneal neovascularization model provides an efficient assay to assess the anti-neovascular properties of drug candidates, offering data on the angiogenesis inhibitor properties of both ocular and non-ocular compounds.

rat IHC controlSingle or multiple sutures are placed in rat or rabbit eyes to induce a foreign body inflammatory response that results in vessel growth from the limbus toward the suture(s). Alternatively, a pro-angiogenic material can be placed in a micropocket in a mouse eye to generate a similar response. Multiple or individual drug concentrations can be screened, and the vessels are measured over time to determine relative drug candidate efficacy.