Overview

Our xenograft model portfolio is evaluated on a regular basis for response to standards of care and this data is available for designing combination studies.

Our scientific staff can assist in selecting the most appropriate model for your agent. Complete profiling of agents can be carried out in a variety of tumor types or in combination with the appropriate clinical agent.

Efficacy evaluation can be combined with:

  • Hematology (CBC/Diff) analysis
  • Pharmacokinetic or bioavailability sampling and analysis
  • Histopathology or tissue sampling
  • Biomarker screening, sampling or evaluation
  • MODELS WITH PROFILE
    Histotype Cell Line*
    Bladder SW780
    Brain SF-295, SK-N-AS, U87 MG, U251
    Breast BT474, HCC-1806, HCC-1954, JIMT-1, MCF-7, MDA-MB-231
    Colon CL-34, COLO 205, DLD-1, HCT 116, HCT-15, HT-29, LoVo, LS-174T, LS411N, RKO, SW48, SW480, SW620
    Epithelial A-431
    Gastric N87, SNU-5
    Head and Neck FaDu
    Leukemia HL-60, MOLM-13, MOLT-4, MV4-11, RS4;11, SET2, THP-1
    Liver Hep3B, HuH-7, SNU-398
    Lung (Non-small cell) A-427, A549, H1299, H1975, H226, H23, H292, H460, H520, H522, H647, H727, H810, HCC-44, NCI-H2122, SK-MES-1
    Lung (Small cell) H69, H82, H211, H526, SHP-77, DMS 114
    Lymphoma Daudi, DoHH-2, Granta 519, JEKO-1, KARPAS-299, MOLT-4, Raji B, Ramos, REC-1, RL, SU-DHL-4, WSU-DLCL2
    Melanoma A2058, A375, IGR-37, UACC-62
    Mesothelioma MSTO-211H
    Multiple Myeloma H929, OPM-2, RPMI 8226
    Neuroblastoma SKNAS
    Ovarian A2780, IGR0V1, OVCAR-3, OVCAR-5, SK-OV-3, TOV-21G
    Pancreas BxPc-3, HPAC, HPAF II, KP4, MIA PaCa-2
    Prostate 22Rv.1, PC3
    Renal 786-0, G-401, G-402
    Sarcoma HT-1080, SJSA-1
    Thyroid 8505C, FTC-238
    Uterine ECC-1, MFE-280
    * Note: Specially requested lines can be developed if a model of interest is not among those listed above.
  • MODELS WITHOUT PROFILE

    Although the models listed below have not yet been profiled for response to current standards of care, tumor growth curve data is available.

    Histotype Cell Line*
    Adrenal H295R
    Breast HCC70
    Ewing's Sarcoma RD-ES
    Gastric MKN-45
    Leukemia HEL92.1.7, K-562, Kasumi-1
    Lung COR-L23, NCI-H1963, H2009, H1581, H1993, H441
    Lymphoma Mino, Namalwa
    Melanoma CHL-1, COLO 800, IGR-1, IGR-37
    Ovarian OV-90
    Pancreas PSN-1
    Prostate DU145, LNCaP, VCaP
    Thyroid K1
    Uterine HEC-1-A, HEC-1-B
    * Note: Specially requested lines can be developed if a model of interest is not among those listed above.