Overview

Human tumor xenografts in a nude rat model are used to conduct in vivo efficacy evaluation of potential cancer therapies. Our broad range of tumor lines ensures a wide variety of testing alternatives.

Our xenograft portfolio is evaluated on a regular basis for response to standards of care and this data is available for designing combination studies.

Our scientific staff can assist in selecting the most appropriate model for your agent. Complete profiling of agents can be carried out in a variety of tumor types or in combination with the appropriate clinical agent. These models are offered as a second species for clients preparing for their IND filing.

Specially requested lines can be developed if a model of interest is not among those listed below:

Tumor TypeCell Line
BrainU87MG
BreastMDA-MB-231
ColonHCT116, HT29
EpidermoidA431
LeukemiaMV4-11, RS4;11, THP-1
LungH460
MelanomaA2058, A375
OvarianA2780
PancreaticMiaPaCa-2
ProstatePC3

Efficacy evaluation can be combined with:

  • Hematology (CBC/Diff) analysis
  • Pharmacokinetic or bioavailability sampling and analysis
  • Histopathology or tissue sampling
  • Biomarker screening, sampling or evaluation