Humanized Mouse Models
Charles River offers two study platforms using humanized mouse models (NOG, NSG, and NCG) engrafted with CD34+ or PBMC. Our models have been characterized with known immune checkpoint inhibitors of clinical relevance to help take the next step in evaluating your compound in immuno-oncology.
We have validated our patient-derived xenograft models as well as our human xenograft portfolio.
|HSC derived from umbilical cord; multiple donors in each cohort.||A single cohort of animals can engraft with a single donor.|
|~Week 15: > 25% huCD45 blood cells||Week 3: ~30% huCD45 blood cells|
|T cell focused||T cell focused|
|Long-term studies (no GvHD)||Short-term studies due to GvHD|
|Number of T cells may vary with multiple donors||GvHD onset varies with donor|
|Less costly approach|
These models can be combined with a variety of tools to enhance your study outcomes, such as: