Overview

Charles River defines patient-derived tumor grafts as explants established as models at low passage numbers (average of six passes removed from patient). They have not been grown in plastic or propagated as cell cultures.

Establishing xenograft tumor models from patient-derived tumor tissue (PDTT) at low passage is believed to conserve original tumor characteristics such as heterogeneous histology, clinical biomolecular signature, malignant phenotypes and genotypes, tumor architecture, and tumor vasculature. Based on this prevalent hypothesis, patient-derived tumor grafts are believed to offer relevant predictive insights into clinical outcomes when evaluating the efficacy of novel cancer therapies.

Tumor Model Compendium
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By leveraging the wealth of information that we have on each tumor model, we can help you with your study and provide suggested patient-derived xenograft (PDX) models to test.

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We currently have more than 400 fully characterized proprietary PDXs in our portfolio, which represent all major histotypes and tumors, and provide extensive background and characterization. Our PDX portfolio includes:

  • Subcutaneous, orthotopic, and disseminated models
  • Extensive molecular and pharmacological characterization, and complete records on patientsā€˜ pretreatment
  • Integrated approach using the same PDX models and/or the corresponding cell line
  • 2D/3D screening assays and subsequent in vivo studies
  • Identification of biomarkers, which predicts tumor sensitivity of compounds
  • Constant addition of new models, which are continuously established through international collaborations with major hospitals and universities

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A High-Content Image Analysis Approach for Quantitative Measurements of Chemosensitivity in Patient-Derived Tumor Microtissues

Learn about the data correlation between in vitro 3D PDX cultures and in vivo PDX tumor models. Read Article


To learn more about our offerings, including molecular information, visit our Tumor Model Compendium.