db/db Mice (JAX™ Mice Strain)

BKS.Cg-Dock7m+/+LeprdbJ
Genetically Engineered
Inbred
db/db JAX™ Mouse
Breeding Location

db/db Mice (JAX™ Mice Strain) Details

db/db mice are used to model phase 1 to 3 of diabetes type II and obesity. Mice that are homozygous for the diabetes spontaneous mutation (Leprdb) demonstrate morbid obesity, chronic hyperglycemia, pancreatic beta cell atrophy and come to be hypoinsulinemic. Affected mice are polyphagic, polydipsic, and polyuric. Obesity begins at three to four weeks of age. The BKS background brings an uncontrolled rise in blood sugar, severe depletion of insulin-producing beta-cells of the pancreatic islets, peripheral neuropathy, myocardial disease and death by ten months. Exogenous insulin results in loss of control of blood glucose levels, while gluconeogenic enzyme activity increases. Metabolic efficiency is increased, while wound healing is postponed. To Charles River from The Jackson Laboratory in May 2002. 

Coat Color
Black

Strain Code
607

Ideal For
Phase I, II, and III type 2 diabetes, obesity research, wound healing

JAX-diabetic-mice-db_db%20Italy%20Growth%20Chart.jpg

Growth chart data should be used as a guideline only.
The shaded areas on each chart are the mean weight plus or minus one standard deviation at a given age averaged across all production facilities. This represents approximately 67% of the population, with the remaining 33% falling outside of this weight range.

db/db Mice (JAX™ Mice Strain) Details

db/db mice are used to model phase 1 to 3 of diabetes type II and obesity. Mice that are homozygous for the diabetes spontaneous mutation (Leprdb) demonstrate morbid obesity, chronic hyperglycemia, pancreatic beta cell atrophy and come to be hypoinsulinemic. Affected mice are polyphagic, polydipsic, and polyuric. Obesity begins at three to four weeks of age. The BKS background brings an uncontrolled rise in blood sugar, severe depletion of insulin-producing beta-cells of the pancreatic islets, peripheral neuropathy, myocardial disease and death by ten months. Exogenous insulin results in loss of control of blood glucose levels, while gluconeogenic enzyme activity increases. Metabolic efficiency is increased, while wound healing is postponed. To Charles River from The Jackson Laboratory in May 2002. 

Coat Color
Black

Strain Code
607

Ideal For
Phase I, II, and III type 2 diabetes, obesity research, wound healing

Growth Chart for JAX™ db/db Mice at CRL Japan

For additional information, including pricing details, please visit the BKS.Cg-Dock7m+/+LeprdbJ mouse page on the Charles River Japan website.

Technical Resources

A Charles River Hosted JAX Webinar™:
Comparing Mouse Models for Obesity and Diabetes Research

black obsese mouse facing diagnol to the front

Want to learn about the strengths and weaknesses of the most popular mouse models of human type 2 diabetes and obesity?

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Comparing Mouse Models for Obesity and Diabetes Webinar: Questions and Answers