NIH-III Nude Mouse

Breeding Location

NIH-III Nude Mouse Details

Most commonly called the NIH-III, it was developed at NIH. In addition to the nude gene, which results in the absence of thymus and T-cell function, this mouse has two other mutations important in regulating the function of the immune system. These are designated as x-linked immune defect (xid) and beige (bg). The xid mutation affects the maturation of T-independent B lymphocytes. It has been demonstrated that bg homozygotes have defective natural killer (NK) cells that are cytotoxic in vitro to tumor cells. However, the extent of the T-independent B lymphocyte and NK cell deficiencies in the NIH-III have not been established.

The control model for the NIH-III nude mouse is the heterozygous NIH-III-HE mouse.

Note: See our isolator page for available immunocompromised animal housing units.

Coat Color
Hairless, light to dark gray pigmented skin
Strain Code
201 (Homozygous)
Ideal For
Tumor biology and xenograft research

Growth Chart Not Available

LOCATION: Wilmington
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