PGP Mouse (P-glycoprotein Deficient) Details
In 1995, a subpopulation of CF-1™ mice with deficient expression of mdr1a P-glycoprotein (PGP) was identified by the department of Safety Assessment, Merck Research Laboratories, West Point, PA. Genotyping led to the identification of homozygous populations, mutant (-/-) and wild-type (+/+), that were developed in conjunction with Merck by Charles River Genetically Engineered Models and Services in Wilmington, MA.
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Coat Color
White (albino)
Strain Code
This model is cryopreserved.
Ideal For
PGP-deficient blood brain barrier model, CNS, transport/excretion involving mds (multiple drug sensitive) for neurobiology and chemotherapy, toxicology, teratology, altered intestinal intraepithelial lymphocyte development
Technical Resources
Technical Reference