PGP Mouse (P-glycoprotein Deficient)

PGP Mouse (P-glycoprotein Deficient) Details

In 1995, a subpopulation of CF-1™ mice with deficient expression of mdr1a P-glycoprotein (PGP) was identified by the department of Safety Assessment, Merck Research Laboratories, West Point, PA. Genotyping led to the identification of homozygous populations, mutant (-/-) and wild-type (+/+), that were developed in conjunction with Merck by Charles River Genetically Engineered Models and Services in Wilmington, MA.

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