PGP Mouse (P-glycoprotein Deficient)

Crl:CF1-Abcb1amds
Outbred
PGP Mouse

PGP Mouse (P-glycoprotein Deficient) Details

In 1995, a subpopulation of CF-1™ mice with deficient expression of mdr1a P-glycoprotein (PGP) was identified by the department of Safety Assessment, Merck Research Laboratories, West Point, PA. Genotyping led to the identification of homozygous populations, mutant (-/-) and wild-type (+/+), that were developed in conjunction with Merck by Charles River Genetically Engineered Models and Services in Wilmington, MA.

Coat Color
White (albino)

Strain Code
This model is cryopreserved.

Ideal For
PGP-deficient blood brain barrier model, CNS, transport/excretion involving mds (multiple drug sensitive) for neurobiology and chemotherapy, toxicology, teratology, altered intestinal intraepithelial lymphocyte development

Bred in

The PGP mouse model is cryopreserved. For more information, contact us at [email protected].

The PGP mouse model is cryopreserved. For more information, contact us at [email protected].

The PGP mouse model is cryopreserved. For more information, contact us at [email protected].