SCID Hairless Congenic (SHC) Mouse Details
The hairless SCID congenic was created in 2009 by Charles River Research Models by using marker-assisted accelerated backcrossing to place the hairless gene (Hrhr) present in the Crl:SKH1-Hrhr stock onto a CB17/Icr-Prkdcscid/IcrIcoCr genetic background. These mice are homozygous for both Hrhr and Prkdcscid mutations, so exhibit the severe combined immunodeficiency phenotype characteristic of SCID mice and are also hairless.
Note: See our isolator page for available immunocompromised animal housing units.
Informational Resources: SHC™ Mouse