ZDF Rat

ZDF-Leprfa/Crl
Inbred
ZDF Rat
ZDF Rat
ZDF Rat
Breeding Location

ZDF Rat Details

A mutation occurred in a colony of outbred Zucker rats in the laboratory of Dr. Walter Shaw at Eli Lilly Research Laboratories in Indianapolis, IN in 1974–75. Part of this colony containing the mutation was moved to Indiana University Medical School (IUMS), to the laboratory of Dr. Julia Clark in 1977. Several groups of animals with diabetic lineage were identified and rederived in 1981. Inbreeding of selected pairs from this rederivation was done in the laboratory of Dr. Richard Peterson at IUMS. An inbred line of ZDF rat was established in 1985. To Genetic Models, Inc. in 1991. To Charles River in 2001.
*Note: We recommend male obese ZDF rats be fed Purina #5008 diet to induce programmed and consistent development of Type 2 diabetes. Female obese ZDF rats express a reproducible Type 2 diabetes phenotype when fed D12468 from Research Diets, Inc.

Coat Color
Black hooded with black stripe down the length of the back

Strain Code
370 (Obese), 380 (Lean fa/+), 371 (Lean +/?)

Ideal For
Type 2 diabetes*, hyperlipidemia, glucose intolerance, obesity, hyperinsulinemia

Growth Chart Not Available

LOCATION: Kingston
UNIT: K83
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ZDF Rat Details

A mutation occurred in a colony of outbred Zucker rats in the laboratory of Dr. Walter Shaw at Eli Lilly Research Laboratories in Indianapolis, IN in 1974–75. Part of this colony containing the mutation was moved to Indiana University Medical School (IUMS), to the laboratory of Dr. Julia Clark in 1977. Several groups of animals with diabetic lineage were identified and rederived in 1981. Inbreeding of selected pairs from this rederivation was done in the laboratory of Dr. Richard Peterson at IUMS. An inbred line of ZDF rat was established in 1985. To Genetic Models, Inc. in 1991. To Charles River in 2001.
*Note: We recommend male obese ZDF rats be fed Purina #5008 diet to induce programmed and consistent development of Type 2 diabetes. Female obese ZDF rats express a reproducible Type 2 diabetes phenotype when fed D12468 from Research Diets, Inc.

Coat Color
Black hooded with black stripe down the length of the back

Strain Code
370 (Obese), 380 (Lean fa/+), 371 (Lean +/?)

Ideal For
Type 2 diabetes*, hyperlipidemia, glucose intolerance, obesity, hyperinsulinemia

ZDF Rat France Growth Chart

ZDF Rat Details

A mutation occurred in a colony of outbred Zucker rats in the laboratory of Dr. Walter Shaw at Eli Lilly Research Laboratories in Indianapolis, IN in 1974–75. Part of this colony containing the mutation was moved to Indiana University Medical School (IUMS), to the laboratory of Dr. Julia Clark in 1977. Several groups of animals with diabetic lineage were identified and rederived in 1981. Inbreeding of selected pairs from this rederivation was done in the laboratory of Dr. Richard Peterson at IUMS. An inbred line of ZDF rat was established in 1985. To Genetic Models, Inc. in 1991. To Charles River in 2001.
*Note: We recommend male obese ZDF rats be fed Purina #5008 diet to induce programmed and consistent development of Type 2 diabetes. Female obese ZDF rats express a reproducible Type 2 diabetes phenotype when fed D12468 from Research Diets, Inc.

Coat Color
Black hooded with black stripe down the length of the back

Strain Code
370 (Obese), 380 (Lean fa/+), 371 (Lean +/?)

Ideal For
Type 2 diabetes*, hyperlipidemia, glucose intolerance, obesity, hyperinsulinemia

Growth Chart for ZDF Rat Colony at Vital River Laboratories in China

Please email us at [email protected] to request a health report for this model.

For additional information, including pricing details, please visit the ZDF rat page on the Vital River Laboratories website.