ZDF Rat (Obese fa/fa)

ZDF-Leprfa/Crl
Inbred
ZDF Rat
Breeding Location

ZDF Rat (Obese fa/fa) Details

A mutation occurred in a colony of outbred Zucker rats in the laboratory of Dr. Walter Shaw at Eli Lilly Research Laboratories in Indianapolis, IN in 1974–75. Part of this colony containing the mutation was moved to Indiana University Medical School (IUMS), to the laboratory of Dr. Julia Clark in 1977. Several groups of animals with diabetic lineage were identified and rederived in 1981. Inbreeding of selected pairs from this rederivation was done in the laboratory of Dr. Richard Peterson at IUMS. An inbred line of ZDF rat was established in 1985. To Genetic Models, Inc. in 1991. To Charles River in 2001.

Control models for the ZDF Rat (Obese fa/fa) are the ZDF Rat (Lean fa/+) or ZDF Rat (Lean +/?).

Note: We recommend male obese ZDF rats be fed Purina #5008 diet to induce programmed and consistent development of Type 2 diabetes. Female obese ZDF rats express a reproducible Type 2 diabetes phenotype when fed D12468 from Research Diets, Inc.

Coat Color
Black hooded with black stripe down the length of the back

Strain Code
370 (Obese fa/fa)

Ideal For
Type 2 diabetes*, hyperlipidemia, glucose intolerance, obesity, hyperinsulinemia

Growth Chart Not Available

LOCATION: Kingston
UNIT: K83
Download the Report

 

ZDF Rat (Obese fa/fa) Details

A mutation occurred in a colony of outbred Zucker rats in the laboratory of Dr. Walter Shaw at Eli Lilly Research Laboratories in Indianapolis, IN in 1974–75. Part of this colony containing the mutation was moved to Indiana University Medical School (IUMS), to the laboratory of Dr. Julia Clark in 1977. Several groups of animals with diabetic lineage were identified and rederived in 1981. Inbreeding of selected pairs from this rederivation was done in the laboratory of Dr. Richard Peterson at IUMS. An inbred line of ZDF rat was established in 1985. To Genetic Models, Inc. in 1991. To Charles River in 2001.

Control models for the ZDF Rat (Obese fa/fa) are the ZDF Rat (Lean fa/+) or ZDF Rat (Lean +/?).

Note: We recommend male obese ZDF rats be fed Purina #5008 diet to induce programmed and consistent development of Type 2 diabetes. Female obese ZDF rats express a reproducible Type 2 diabetes phenotype when fed D12468 from Research Diets, Inc.

Coat Color
Black hooded with black stripe down the length of the back

Strain Code
370 (Obese fa/fa)

Ideal For
Type 2 diabetes*, hyperlipidemia, glucose intolerance, obesity, hyperinsulinemia

ZDF Rat France Growth Chart

Growth chart data should be used as a guideline only.
The shaded areas on each chart are the mean weight plus or minus one standard deviation at a given age averaged across all production facilities. This represents approximately 67% of the population, with the remaining 33% falling outside of this weight range.

ZDF Rat (Obese fa/fa) Details

A mutation occurred in a colony of outbred Zucker rats in the laboratory of Dr. Walter Shaw at Eli Lilly Research Laboratories in Indianapolis, IN in 1974–75. Part of this colony containing the mutation was moved to Indiana University Medical School (IUMS), to the laboratory of Dr. Julia Clark in 1977. Several groups of animals with diabetic lineage were identified and rederived in 1981. Inbreeding of selected pairs from this rederivation was done in the laboratory of Dr. Richard Peterson at IUMS. An inbred line of ZDF rat was established in 1985. To Genetic Models, Inc. in 1991. To Charles River in 2001.

Control models for the ZDF Rat (Obese fa/fa) are the ZDF Rat (Lean fa/+) or ZDF Rat (Lean +/?).

Note: We recommend male obese ZDF rats be fed Purina #5008 diet to induce programmed and consistent development of Type 2 diabetes. Female obese ZDF rats express a reproducible Type 2 diabetes phenotype when fed D12468 from Research Diets, Inc.

Coat Color
Black hooded with black stripe down the length of the back

Strain Code
370 (Obese fa/fa)

Ideal For
Type 2 diabetes*, hyperlipidemia, glucose intolerance, obesity, hyperinsulinemia

Growth Chart for ZDF Rat Colony at Vital River Laboratories in China

Please email us at [email protected] to request a health report for this model.

For additional information, including pricing details, please visit the ZDF rat page on the Vital River Laboratories website.