Target, Mechanism & Disease Biomarkers

From early discovery stages through clinical support, translational biomarkers are used to identify a compound’s impact on organs or tissues before a clinical effect is evident. Biomarkers are divided into three general classes: target biomarkers, mechanism biomarkers and disease biomarkers. Choosing the right translational biomarker is based on whether it is detectable, measurable and, in the end, able to be qualified or validated. Charles River advises on selecting the appropriate biomarker, analytical methodology and pull through from nonclinical to clinical use. Our biomarkers services include:

  • Fit for purpose to full compliance
  • Full method development, transfer or commercial kit optimization
  • Qualification or validation of target specific assays

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Fluid Biomarker Assay Examples

  • LC-MS
    • Lipids
    • Endocannabinoid-related compounds: AEA, OEA, PEA and LEA
    • Nucleosides and nucleotides
    • Small organic acids
    • Endocrines
    • Neurotransmitters
    • Cytokines
    • Chemokines
    • Lymphokines
    • Hormones
    • Growth factors
    • Steroids
    • Complement factors
    • Injury markers
    • Validated biomarker assays