DMPK Studies
We have scientists dedicated to both discovery and development, allowing lead candidate selection to flow seamlessly into the development phase. Our discovery and research specialists offer customized screening programs to ensure early and late lead candidate optimization. Development studies are designed to satisfy the requirements of international regulatory authorities and to provide safety data to assess the validity of laboratory species as appropriate toxicological models for humans. Our drug metabolism facilities are networked and utilize validated data management systems for data capture, storage and evaluation.
| ADME/DMPK: Where Discovery Meets Development | ||
|---|---|---|
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| Compound Identification & Lead Optimization | Candidate Nomination | Lead Candidate Testing |
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Discovery compound(s) identification Pre-lead optimization 100s of compounds / in vitro ADME Data feedback to medicinal and synthetic chemists 10s of compounds / single species PK |
Typically 1-5 compounds |
In vivo radiolabelled ADME in toxicology species and in support of special populations |