Physicochemical Characterization

Physicochemical testing is an integral requirement of product registration for agrochemicals, biocides, chemicals and animal health products. Charles River Laboratories offers all the characterization and physicochemical studies (active ingredients and formulated products) necessary to support registration worldwide.

Physicochemical Studies

  • Physical state
  • Melting point
  • Boiling point, relative density
  • Surface tension
  • Water solubility
  • Organic solvent solubility
  • Octanol/water partition coefficient
  • Dissociation constant
  • Flammability
  • pH
  • Viscosity
  • Oxidizing or reducing properties
  • Rate of hydrolysis (cold)
  • Spectra (UV, UV/Vis, IR, NMR, MS)

Stability Testing

The storage stability and shelf-life of the formulated product can be determined under a variety of specified storage conditions. Solid, liquid, semi-solid and aerosol formulations can all be evaluated using real-time and accelerated storage stability testing. We have dedicated facilities to stress the material using monitored heat, humidity or light parameters.

Platforms

  • HPLC (UV, LIF, fluorescence, refractive index, light scattering, electrochemical)
  • GC (FID, NPD, TCD, ECD)
  • LC-MS, GC-MS, GC/LC-MS-MS, time-of-flight (Q-ToF, IT-ToF)
  • Capillary electrophoresis (UV, LIF)
  • Dionex ion chromatograph (conductivity)
  • ICP-OES (Optima™ 8000)