Physicochemical Characterization

Your timelines depend on our ability to meet commitments, regardless of challenges that may arise. With a full range of physicochemical testing capabilities to meet all regulatory requirements, Charles River has carried out many successful programs involving various pesticide classes, including insecticides, herbicides, fungicides and biocides. We have also worked with a wide variety of industrial chemicals, including dyes, flavor and fragrance substances, monomers, fluorinated chemicals and inorganics. Data have been successfully accepted in support of numerous registrations throughout Europe, North America and Asia.

With a staff of more than 20 scientists dedicated to this discipline, our team completes approximately 300 analytical packages per year. We specialize in the physicochemical testing of  a wide variety of materials, ranging from pure, stable substances up to complex mixtures and UVCBs as well as reactive matter. Our experts have experience in the full array of analytical techniques, including LC, LCMS, GC, GCMS and ICPSMS and can provide analytical support for both storage stability as well as physicochemical characterization.

Our scientists are also able to provide a number of physicochemical test expert  statements, with or without the use of screening techniques such as DSC, to offer our clients the most economical testing strategies.

Physicochemical Testing Services

  • Physical state
  • Melting point
  • Boiling point, relative density
  • Surface tension
  • Water solubility
  • Organic solvent solubility
  • Octanol/water partition coefficient
  • Dissociation constant
  • Flammability
  • pH
  • Viscosity
  • Oxidizing or reducing properties
  • Rate of hydrolysis (cold)
  • Spectra (UV, UV/Vis, IR, NMR, MS)

Storage Stability Testing

The storage stability and shelf-life of the formulated product can be determined under a variety of specified storage conditions. Solid, liquid, semi-solid and aerosol formulations can all be evaluated using real-time and accelerated storage stability testing. We have dedicated facilities to stress the material using monitored heat, humidity or light parameters.

Analytical Platforms

  • HPLC (UV, LIF, fluorescence, refractive index, light scattering, electrochemical)
  • LC-MS, GC-MS, GC/LC-MS-MS, time-of-flight (Q-ToF, IT-ToF)
  • Capillary electrophoresis (UV, LIF)
  • Dionex ion chromatograph (conductivity)
  • ICP-OES (Optima™ 8000)