This benchtop system is comprised of five individual spectrophotometers built into a unit with a single Ethernet connector that links to your computer running EndoScan-V™ version 5.5.5 or higher, our 21 CFR Part 11 compliant-ready endotoxin measuring software. Since each cartridge runs independently, you can run your samples as needed and not wait for a full batch of samples for testing, obtaining results in approximately 15 minutes.

Interested in improving your lab’s efficiency? Learn why over 5,000 organizations have adopted this rapid and proven technology to streamline their manufacturing processes.

Product Validation with the MCS™

The Endosafe-MCS™ and our FDA-licensed LAL cartridges are validated for bacterial endotoxin testing and can be used for product validation for both previously validated samples and new products.
Find out how


    Charles River is committed to producing environmentally friendly products as part of the EU Directive on Restriction of the use of certain Hazardous Substances (RoHS). With the release of the Endosafe® nexgen-MCS™ and as part of our End-of-Life policy, the original Endosafe®-MCS™ (MCS100K and MCS550K) is discontinued. The Endosafe® nexgen-MCS™consists of upgraded components in an effort to ensure compliance with the RoHS directive. Support for first generation systems (including parts, maintenance and calibration) will continue through December 31, 2022. Beginning in 2023, support for first generation MCS™ systems will be limited.

    • Test multiple samples simultaneously
    • Samples run independently, allowing for random access
    • High throughput for real-time results
    • Single-step, semi-quantitative LAL test
    • Uses FDA-licensed LAL cartridges
    • LAL test components all included in cartridges
    • Results can be analyzed via EndoScan-V™ endotoxin measuring software.
    • Sophisticated data management and reporting capabilities
    • Samples can be traced to the individual spectrophotometer used to perform the assay.
    • Four levels of sensitivity are available as testing options: 0.005, 0.01, 0.05 and 0.10 EU/ml.
    • No microbiology training is required; anyone can run this simple assay.
    • System qualification and validation support is provided if needed.