Overview

Based on MALDI-TOF mass spectrometry, the MALDI Biotyper has become widely accepted across industry segments as the next generation of microbial identification. While conventional biochemical identification takes time-consuming incubation and ancillary precursory tests after selecting the microbes from the culture plate, the Axcess® System allows for instantaneous identification of isolated colonies from a plate.

Video Demonstration

Axcess® System Features

  • Bruker MALDI Biotyper: Automated self-cleaning, silent bench-top system with enhanced peak resolution, sensitivity and performance.
  • Annual Axcess® Classification: A classification is based on the number of identifications obtained from the Accugenix® bacterial database.
  • Accugenix® MALDI-TOF Reference Library: The largest curated database focused on identification of microorganisms in aseptic and non-sterile manufacturing environments.
  • No-Match Sample Guarantee: Complimentary AccuPRO-ID® service to test samples that fail to yield a successful species identification.
  • Fungal Samples: Axcess® customers receive a discounted rate for the identification of filamentous fungal samples utilizing our AccuGENX-ID® FunITS service.
  • Security: Our IT approach is purposely designed with multiple redundancies to protect your data and to ensure continuity of service 24/7.
  • Tracking and Trending through Our Customer Web Portal: The Accugenix® Customer Web Portal makes it easy to get a glimpse of your environmental control data, past and present. Filterable reports help you note significant changes in microbial flora when investigating excursions or conducting root cause determinations.
  • System Throughput: Workflow analysis has shown that 4 target plates containing 48 spots each can yield results in 60 minutes (15 minutes/target plate), compared to competitive MALDI-TOF systems that can take up to 180 minutes for the same workload or phenotypic systems that can take up to 18 hours of incubation time for biochemical reactions to occur.

 

  • Partnership Agreement with Bruker to Sell the Axcess System

    On April 15, 2013, Charles River was pleased to announce a partnership with Bruker to provide rapid, accurate microbial identifications to the industrial microbiology market, including pharmaceutical, biopharmaceutical, personal care and other manufacturing industries. Through this agreement, the Charles River Endotoxin and Microbial Detection division will sell the Axcess™ System, an offering that combines the Bruker MALDI Biotyper system with a custom data analysis software solution that allows instantaneous access to the Accugenix® microbial database for identifications.

    By combining the precision and robustness of the Bruker MALDI Biotyper technology with the Accugenix® cGMP-compliant microbial database and software, the Axcess™ System can maximize performance for environmental monitoring applications while simplifying customers’ validation commitment.  As the Accugenix® database is frequently updated to reflect the inclusion of novel organisms relevant to industrial manufacturing facilities, customers will always have access to the most current and validated database for identifications, saving time and costs associated with validating library releases. Included in the Axcess™ System offer, Charles River will provide sequence-based identifications for those isolates that fail to be identified by the MALDI Biotyper, minimizing the customer’s need for a secondary system. By generating accurate and consistent microbial identification through this offer, manufacturing sites will be better able to reliably track and trend their facility for routine gridding studies or possible excursions.

    Dr. Gary Kruppa, Vice President of Business Development at Bruker Daltonics, stated: “We are delighted to be working with the Endotoxin and Microbial Detection division of Charles River on distribution of the MALDI Biotyper into the industrial and pharmaceutical microbiology markets. From my experience, the technical and sales teams that Charles River brings to this effort are among the best and most respected in these industries. With Charles River products in virtually every pharmaceutical microbiology laboratory, we are looking forward to working with Charles River to expand our efforts to make the MALDI Biotyper the new standard in microbial identification for industrial microbiology.”

    “By partnering with Bruker Daltonics, the recognized industry leader in MALDI-TOF mass spectrometry, we have reinforced our mutual commitment to meeting our customers’ microbial identification needs with innovative and comprehensive environmental monitoring solutions. Our entire team here at Charles River is excited to introduce the Axcess™ System to the market and to represent the MALDI Biotyper by providing the same professionalism, responsiveness and expertise Bruker is known for,” stated Foster Jordan, Corporate Senior Vice President, Charles River Endotoxin and Microbial Detection.