Automated Endotoxin Testing System

Performing endotoxin testing on large numbers of samples using traditional methods can be both time-consuming and susceptible to outside influences, such as technician errors and standard curve anomalies. The time required to prepare standards and samples can often exceed the assay time while simultaneously tying up valuable resources.

nexus instruments

As manufacturing and technology evolve, your organization should be looking at changing methods that are heavily dependent on human interaction. Moving to automated endotoxin testing will help to lower your coefficient of variations, reduce ergonomic issues, save lab analyst time, and reduce standard curve variability. Endotoxin automation is the most efficient standard of testing in your lab. 


Maintain Control of Your QC Processes

Traditional bacterial endotoxin tests using a duplication (i.e., repeating the same task or effort in order to identify or avoid error) method to mitigate human risk, such as the "four eyes principle," are the least effective at preventing human error, while endotoxin automation is the most effective, as it is less reliant on subjective data.

By reducing human error in processes, they are not only more efficient, but they also increase the quality of products produced, thus positively impacting patients and their safety.

How does the Endosafe Nexus work?

Lab technician demonstrating Endosafe Nexus Automated Endotoxin Testing

Learn how to use the Nexus automated endotoxin testing system in this comprehensive virtual demonstration video series.



User Benefits Endosafe Nexus Automated Endotoxin Testing System

  • Data Integrity
    • Bar-coding technology enhances data management and reduces input errors and the need for subsequent investigations.
    • Full, searchable audit trail, with every action recorded to ensure data integrity. Add Charles River Cortex™ for an integrated solution to securely consolidate, query, and analyze all real-time endotoxin data for necessary internal QA and FDA trending reports.
    • Addresses increased focus on data integrity by regulators, minimizing risk of most commonly cited events.
  • Lab Efficiency
    • Hands-off rapid automated endotoxin testing system with the ability to test up to 60 samples per run.
    • Automated dilution and sample handling with the ability to suspend current run.
    • Can be utilized for central lab water testing and product testing.
  • Product Codes
    Product Code
    Nexus robotic system 24-tube racks
    nexgen-MCS™ instrument
    Nexus™ integrated software
    Anti-static mat
    Nexus robotic system 32- tube racks
    nexgen-MCS™ instrument
    Nexus™ integrated software
    Anti-static mat
    Sterilized conductive 300 μL tips case
    (5,760 per case)
    Sterilized conductive 1 mL tips case
    (3,840 per case)


Did You Know Endosafe LAL Cartridges Are a Compendial BET Method?

Charles River's comprehensive biologic testing solutions includes stability testing.

FDA-licensed Endosafe LAL cartridges are a kinetic chromogenic LAL method as specified in the EP/USP and JP. See the regulatory requirements here:

FDA Guidelines
USP BET <85> or EP BET <2.6.14>


How The Nexus Process Works


Frequently Asked Questions (FAQs) About Endosafe Nexus