Traditional Kinetic Chromogenic Assay Reagents
Endochrome-K™, our traditional LAL kinetic chromogenic assay (KCA) facilitates your endotoxin screening with its ease of use and unique reagent stability. Featuring an optimized 0.005 EU/mL sensitivity*, our traditional kinetic chromogenic assay reagent provides heightened sensitivity for more accurate results, greater linearity for endotoxin analyses, and superior interference resistance. Our traditional LAL kinetic chromogenic reagent is designed to enhance your kinetic chromogenic assay and rapidly deliver accurate results.
*Lower sensitivity lots available on request, reach out to your local representative if you require a more sensitive lysate.
Looking for rapid kinetic chromogenic testing?
Same kinetic chromogenic testing, but in a cartridge built for efficiency, flexibility and sustainability. Learn how your lab can get test results in as little as 15 minutes and use 95% less LAL.
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Endosafe® Kinetic Chromogenic LAL Reagents
Product Code Endochrome-K™ kit - 256 tests
(sensitivity= 50-0.005 EU/ml)
8 X 3.2 mL vials
2 X 10 ng control standard endotoxin
3 X 30 mL LAL reagent waterR1708K Endochrome-K™ vial pack - 320 tests
(sensitivity= 50-0.005 EU/ml)
10 X 3.2 mL vialsR1710 Endochrome-K™ bulk pack - 3,200 tests
(sensitivity= 50-0.005 EU/ml)
100 X 3.2 mL vialsR17100 Endpoint chromogenic kit (140 tests)
5 × 1.4 mL vials of chromogenic LAL
1 × 10 mg vial of chromogenic substrate S-2423
2 × 2 ng vials of endotoxin
2 × 30 mL vials of LAL reagent water
1 × 15 mL 0.05 M vial of Tris bufferR160K
We've developed and optimized a range of quantitative and qualitative LAL formulations providing an unrivaled combination of sensitivity, linearity, and interference resistance. Find out more about Charles River's kinetic turbidimetric LAL and our other bacterial endotoxin testing solutions.
Frequently Asked Questions (FAQs) About LAL Kinetic Chromogenic Assays
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What is the difference between the LAL kinetic chromogenic assay and LAL kinetic turbidimetric assay?
Both the kinetic chromogenic assay and the kinetic turbidimetric assay are used to detect the presence of endotoxins – one by color, and one by turbidity. When the kinetic chromogenic LAL reagent reacts with endotoxins, the reagent turns the mixture yellow. Kinetic turbidimetric assays uses the change in turbidity to detect the presence of endotoxins.
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What endotoxin testing instruments can be used with the LAL kinetic chromogenic assay?
Charles River offers a number of testing platforms that are compatible with the kinetic chromogenic assay. The Endosafe® nexgen-PTS™, Endosafe® nexgen-MCS™, and the Endosafe® Nexus utilize rapid chromogenic LAL assays and are designed for ease-of-use and compatibility. Additionally, traditional kinetic chromogenic LAL can be run utilizing a BioTek® microplate reader.
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How does the LAL kinetic chromogenic assay work?
The LAL kinetic chromogenic assay works in the presence of a colorless substrate when the enzymatic reaction will cause a yellow color to develop upon cleavage of the chromophore, p-nitroaniline (pNA). pNA liberation can be measured spectrophotometrically.
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Where do I find verification that the kinetic chromogenic LAL assay is a compendial method?
The kinetic chromogenic LAL assay is a compendial method per USP <85> and EP <2.6.14>.