AAV Antibody Testing Solutions for NHPs

Adeno-associated viruses (AAVs), harmless cold viruses ubiquitous in nature, are critical components in the development of gene therapies for patients. As shown below, there are at least 13 known serotypes of adeno-associated virus which differ in their ability to infect certain tissues or cell types, making adeno-associated virus a useful system for preferentially transferring a gene therapy to a specific cell type. Recently, several gene therapies have been developed utilizing adeno-associated viruses as the primary delivery vector, and more are coming with more than 200 gene therapy trials currently in development utilizing AAVs.

Table 1: Summary of tropism of different AAV serotypes including preferred tissue types for infection.

Optimal Serotype
Neutralization Assay Status
CNS, Kidney, Photoreceptor cells, RPE (Retinal Pigment Epithelium)
Available now
CNS, Heart, Liver, Lungs, Skeletal muscle
Available now
Additional Serotypes
Wide range of tissues
In development

Nonhuman primates (NHPs) are key translational models in the development of gene therapies. As such, when working with NHPs it's important to know if these animals have neutralizing or non-neutralizing antibodies induced following pre-exposure to particular serotypes to maximize delivery and efficacy of the gene therapy to target tissues for high GFP expression.

We're now pleased to offer serology and PCR-based antibody testing assays for AAV2 and nine serotypes for researchers working with NHPs in gene therapy research.

Adeno-associated Virus Neutralizing Antibody (NAb) Assays

NAb screening assay
(+ or – at dilution of 1:10, 1:20, and 1:40)
Qualitative assay at various dilutions to detect the presence of pre-existing neutralizing antibodies.
NAb titer assay
(serum titration from 1:10-1:5,120)
Quantitative assay to measure concentration or titer of antibody in serum.

Why Use Our AAV Antibody Testing Services?

  • Two assays available to measure neutralizing antibodies qualitatively and quantitatively
  • Rapid turnaround time, with sample testing time in just two weeks
  • Superior quality and competitive pricing
  • We accept samples from anywhere in the world every day
  • May be able to transfer client’s custom assays in-house to perform routine screening
  • PCR assays available to detect different adeno-associated viruses in serum and different tissue types
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Frequently Asked Questions (FAQs) About Adeno-associated Virus (AAV) Neutralizing Antibody Testing