SCID Mouse Models

SCID mice possess a genetic autosomal recessive mutation designated Prkdcscid.** They are homozygous for the Prkdcscid allele, which has been mapped to the centromeric end of chromosome 16. These mice have severe combined immunodeficiency affecting both B and T lymphocytes.

They lack functional lymphocytes because of impaired VDJ rearrangement (rearrangement of separate gene elements of the immunoglobulin and T-cell antigen receptor genes). While typical SCID mice are haired, our portfolio includes hairless models that make ideal candidates for tumor imaging and measurements:

* Download xenograft data for the Fox Chase SCID mouse and Fox Chase SCID Beige mouse.

** Please note that the Prkdcscid mutation makes these mice more sensitive to radiation and certain drugs that may impair their DNA, compared to mice that don’t carry the mutation. Due to their sensitivity, SCID mouse models are not optimal for use in research that includes radiation. To determine the appropriate dosing and/or route of administration, a drug tolerance study is recommended.
 

Frequently Asked Questions (FAQs) About SCID Mice