Humanized Mouse Models
The use of humanized mice as in vivo models has become commonplace in studies for immuno-oncology and infectious disease research. They have also improved the ability to predict human responses to new drugs being clinically developed.
Depending on research requirements, it is critical that researchers have the ability to obtain study-ready animals or maintain the option to humanize the mice in-house to meet their project timelines.
When your research requires humanized animal models, Charles River offers two options, both founded on the NCG triple-immunodeficient mouse.
Currently, the Charles River NCG triple-immunodeficient mouse model is the foundation for our humanization portfolio. Its unique phenotype allows it to host xenograft cells, tissue, and human immune system components. It displays noticeable improvements of foreign tissue transplantation and engraftment, compared to previous generations of immunocompromised mice.
The NCG mouse is best suited for studies on tumor biology, immuno-oncology, infectious diseases, graft-versus-host disease (GvHD), hematopoiesis, and tissue transplantation.
PBMC Humanized Mouse
Immunodeficient mouse models engrafted with human peripheral blood mononuclear cells (PBMCs) are available for short-term studies. In our hands, engrafted human cells can be detected as early as 10 days after injection of the PBMCs. A good proportion of these adult immune cells are of human T-cell origin (CD4+ and CD8+).
The ability of human immune cells to engraft in the NCG mouse makes it a powerful tool to evaluate compounds for immuno-oncology, GvHD, infectious diseases, and inflammatory diseases.
Choose the option that's best for you:
- Purchase study-ready huPBMC-NCG mice*
- Create your own humanized model using our NCG/PBMC select humanization kit
*NCG mice shipped already injected with PBMC cells are available in North America only.