HuCD34-NCG Mouse Model

The HuCD34-NCG mouse from Charles River is a study-ready mouse model with a human-like immune system, created by adoptive transfer of CD34+ stem cells. HuCD34-NCG mice are an ideal in vivo platform to evaluate the effectiveness of compounds modulating the human immune system. The lack, or late onset, of graft-versus-host disease (GvHD) in humanized mice make them ideal for long-term studies.

NCG mice are humanized by adoptive transfer using human umbilical cord blood-derived CD34+ stem cells from a qualified source, following myeloablation treatment. Animals are subsequently housed for 12-15 weeks according to Charles River immunodeficient animal housing protocols.

Interested in Trying Out the HuCD34-NCG Mouse?

HuCD34-NCG mouse modelThe new CD34+ humanized mouse model is available for evaluation through our Charles River Hu-Mouse™ Exploratory Program.

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During this period, CD34+ stem cells develop into human immune cells that engraft within the immunodeficient NCG mice. The presence of human immune cells are verified in the peripheral blood as early as 12-15 weeks post-engraftment, as verified by multi-color flow cytometry. These immune cells are detectable in mouse tissues, including bone marrow, spleen, liver, and lung, and have been shown to infiltrate implanted tumors.

The HuCD34-NCG mouse model is available in North America only.


Benefits of the HuCD34-NCG Mouse Model

  • Convenient – HuCD34-NCG mice are study-ready, expressing human immune cells
  • Consistent – Every mouse is pre-tested for humanization
  • Stable – Engraftment of hematopoietic cells provides a research platform for extended studies 
  • License-free – No additional licensing fees or royalty payments


Research Applications

  • Oncology
  • Immunology
  • Hematopoiesis
  • Stem cell research
  • Infectious disease
  • Regenerative medicine
  • Transplantation research
  • Hematological disease


For more information on this model, download the HuCD34-NCG Mouse product sheet.
 

Pricing and Ordering Information

  • Pricing

    Prices include the HuCD34-NCG model, as well as the cost of the multicolor flow cytometry testing per mouse.

  • How to Order

    Place your order for the HuCD34-NCG mouse today by contacting Charles River at 1.800.LABRATS (1.800.522.7287) or via email at [email protected].

    Available in North America only.

Frequently Asked Questions (FAQs)