Genetically Engineered Mice & Rats
With decades of experience and the largest network of vivariums in the world, we take pride in our ability to offer an unparalleled selection of genetically engineered animals and services to meet the unique needs of your program. Our full-service portfolio includes custom breeding, embryology, genetic testing, drug discovery, and safety assessment services. Additionally, through our collaboration with genOway, we offer knockout mouse models for use in in vivo studies.
Services for Genetically Engineered Animals
Rat & Mouse Colony Management
Our full service, colony management program for genetically engineered animals delivers animals when you need them. Services include breeding and animal holding, quarantine, IVF expansion, line recovery, and speed congenics.
Transgenic Mouse & Rat Model Creation
Generate and distribute transgenic lines using CRISPR/Cas9. Gene editing, custom RNAi, ES cell mutagenesis, knockin and knockout, and microinjections are some of the services offered for model creation of mice and rats.
Genetic Testing Services
Maintain genetic integrity by using a genetic testing program. Geneticists provide guidance and consultation for colony management and breeding strategy. Genotyping, assay development, and background characterization are some of the core services offered.
Embryology services ensure the access to original stock, no matter the circumstance. Cryopreservation, rederivation, colony development, and line rescue are just a few of the options that provide an alternative to maintaining live animals for strains that are not being used, but may be needed in the future.
Rapid Colony Development
Speed up the process of establishing animal colonies. Using IVF, a small colony of animals can generate hundreds or thousands of animals to create a study-ready colony.
Assess animal health status and guard against facility contamination. Isolator-based animal quarantine allows for direct acceptance of genetically engineered animals from any institution, regardless of their health status.
Our line rescue services can diagnose, plan, and recover breeding colonies, allowing research and breeding to continue.
The project management program includes a dedicated project manager for every project to understand it’s unique goals and challenges. Additional support from veterinarians, geneticists, embryologists, and other dedicated scientists is available, along with access to an online colony management system for real-time data.
Frequently Asked Questions (FAQs) about Genetically Engineered Animals
What are genetically engineered mice?
Genetically engineered mice have their genome altered and are used for gene research and in human disease studies.
What is the advantage of working with Charles River to obtain animals that have been genetically engineered?
With Charles River you’ll receive:
- Advice from experienced scientific teams utilizing a variety of techniques.
- Strict adherence to project timelines for creating genetically engineered animals.
- Access to, and advice on, CRISPR licensing, with ownership of intellectual property.
- A high health status with breeding under VAF/Plus® (SOPF) standards.
- A high degree of model validation and analysis to ensure your new model generates consistent study data.
What species does Charles River work with for genetically engineered animal model creation, breeding, and embryology support services?
At Charles River, we are experts not only with genetically engineered mice, but also with transgenic animals and knockout rats.
What are some of the advantages of using knockout mouse models?
The gene knockout method is the simplest approach to reveal fundamental gene functions. Conditional knockout/inducible mice, inducible knockout mice, and knockdown mice can avoid the risk of a lethal phenotype associated with gene inactivation at earlier stages in development and allow for an analysis of gene inactivation effects on adult animals. Furthermore, as 65% of protein coding genes are likely pleiotropic, a conditional knockout mouse simplifies phenotyping analysis by focusing on a specific cell type.
Is there a colony management program for mice and rat breeding?
We provide a full-service animal colony management program for genetically engineered animals that delivers animals in the exact quantity and health status you require. Our staff works with you to deliver cohorts of animals and develop and execute mouse or rat breeding plans.
Is there an online tool for animal colony management?
In addition to providing breeding services, our Internet Colony Management (ICM)™ system complements our breeding services and comprehensively supports your colonies. ICM™ allows real-time communication to ensure the data is accurate and project goals are aligned. It securely stores project information and documentation online to simplify record keeping. Customers can easily find the data they need quickly by the extensive filtering and sorting features in the system.
- What services are offered for genetically engineered mice and rats?