Overview

Charles River can remove adventitious organisms, such as viruses, bacteria, and parasites, from your mice and rats with our rederivation services. Your rederived animals will meet our VAF/Elite® health status and will be maintained in a biosecure isolator environment to protect the health of your colony. We have rederived over 10,000 unique strains of mice and rats with 100% removal of unwanted organisms.

Embryo Rederivation: Recommended for use with homozygous lines, lines with multiple genetic mutations or rats. Your non-rederived live colony will be maintained until your deliverables are met.

Sperm Rederivation: Recommended for use with nonhomozygous, single mutation mouse lines.

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ServiceRequirementsDeliverablesEstimated Timeline
Rapid Rederivation – Embryo and SpermMouse:
  • 2-5 males: < 6 months old
  • 10 females: 3-4 weeks old
Rat:
N/A
  • Minimum 2 visibly pregnant, embryo recipient females
  • VAF/Elite® mice
6 weeks
Embryo Rederivation with Health ReportMouse:
  • 2 males: < 6 months old
  • 10 females: 3-4 weeks old
Rat:
  • 4 males: < 6 months old
  • 10-15 females: 10-12 weeks old
  • Minimum 10 offspring with complete health report
  • Conventional colony held until project completion
  • For homozygous x homozygous strains
  • VAF/Elite® mice or rats
12-15 weeks
Sperm Rederivation with Health ReportMouse:
  • 2 males: < 6 months old
  • 10 females: 3-4 weeks old
Rat:
N/A
  • Minimum 10 offspring
  • Complete health report
  • Sperm cryopreservation
  • For homozygous x homozygous strains
  • VAF/Elite® mice
12-15 weeks
Embryo Rederivation with Homozygous Expansion BreedingMinimum of 5 breeding pairs
  • Minimum 10 offspring with complete health report
  • Conventional colony held until project completion
  • For homozygous x homozygous strains
  • VAF/Elite® mice or rats
6-9 months