Supporting Biomedical Research Programs
For more than 60 years, researchers around the world have relied on Charles River to support their critical research employing transgenic animals.
Services We Offer for Transgenic Animals
- Mouse & Rat Breeding
- Genetic Testing Services
- Embryology Services (including cryopreservation and rederivation)
- Rapid Colony Development
- Animal Quarantine
- Line Rescue
Creation of New Transgenic Animals
Through partnerships with genomic industry leaders, we offer complete solutions for customized mouse and rat model creation using technologies and techniques that include CRISPR/Cas9, ES cell mutagenesis, and RNAi.
Our combined in vitro and in vivo knowledge provides both genetic design and breeding expertise, so you get the most relevant models for your studies. We offer strict quality controls, fast turnaround, and dedicated project managers to guide you through your projects.
Frequently Asked Questions (FAQs) About Transgenic Animals
Are all genetically modified animals transgenic, and what is the difference?
Genetically engineered animal models are mutant animals whose genetic material has been modified through genetic engineering techniques, rather than a mutation that occurs naturally by mating and/or natural recombination.
Transgenic animals, specifically, are those that have had DNA from an external source inserted into their germ line, and it may or may not be targeted to a specific location in the genome. This is why the term "knockout animal" (where a targeted gene is made inoperative) or other more specific terms are often used when describing different types of genetically modified mutant animal models.
What are some things to watch out for when genotyping transgenic animals?
Please read five key points to watch for when genotyping transgenic models to ensure the genetic integrity of breeding colonies.
Where can I find additional information on transgenic animals?
Please visit these resources: