Custom Rat & Mouse Model Generation

Effective research depends on finding the most relevant animal model for your project. Our team can select, customize, create, and maintain the right transgenic model specific to your research by using CRISPR/Cas9* technology. Through a strategic partnership with our genomics partners, we're able to offer transgenic model creation and design to clients around the world.

Our experienced project management team, scientists, and animal care staff are available to offer guidance, develop work plans, and help overcome any challenges you may face.

Rodent model genetic quality control guidebook for genetic monitoring

New Guidebook: Rodent Model Genetic Quality Control

Managing a genetically engineered rodent colony is not so simple. Get our new guidebook to obtain sound advice on colony management, genetic monitoring and embryology techniques required to protect your research.

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Model Creation Services

  • CRISPR/Cas9* Genome Editing in Mice and Rats

    Create and maintain the right transgenic model for your study using CRISPR/Cas9. This technology is used to knockout or modify DNA in animal models to study phenotypes and develop new treatments. Using genetic transfer into embryos or embryonic stem cells based on the needs of your project, transgenic animals can be obtained in 3 – 4 months.

  • RNAi Mouse Models

    RNAi-mediated gene silencing makes complex genetic modifications easier to achieve more quickly and efficiently than traditional knockout technologies. The estimated timeline from project initiation to the generation of ES cell-derived RNAi mice is an estimated 24 – 30 weeks.

  • ES Cell Mutagenesis in Mice

    Using ES cell technology, our experts inject custom embryonic stem (ES) cells directly into blastocysts, effectively bringing your in vitro research models to life.

  • Knockout Mice

    Knockout mice are used to study gene function and validate treatments. Whether you're looking for constitutive, conditional, or RNAi knockout mice, we can deliver study-ready knockout cohorts to meet your research needs.

  • Knockin Mice

    The ability to engineer the mouse genome has made transgenic mice a powerful tool to model human disease. All types of mutations for knockin mice are achievable, whether it’s constitutive, point mutation, or humanized mice.

  • Microinjection Services

    Bridge the gap between your in vitro and in vivo mouse models by using ES cell, DNA, and CRISPR microinjections.

  • Random DNA Transgenesis in Mice

    The DNA vector is injected directly into the pronuclei of zygotes, bringing your customer in vitro models to life with founders available in 3 – 4 months.

Leverage Your Genetic Toolbox


Frequently Asked Questions (FAQs) About Transgenic Model Creation

* CRISPR-Cas9 used under licenses to granted and pending US and international patents from The Broad Institute and ERS Genomics Limited.