Transgenic Model Creation Services

Charles River works with global customers on unique transgenic models to deliver study-ready cohorts to meet research needs. Our dedicated project management team, scientists, and animal care staff are always available to offer guidance, develop work plans, and help overcome any challenges.


Global Service Offerings

Through partnerships with genomics industry leaders, our combined expertise provides an optimum environment for generating, characterizing, preserving, and distributing your transgenic lines.

  • CRISPR/Cas9 Genome Editing in Mice and Rats

    Create and maintain the right model for studies using CRISPR/Cas9. This technology is used to knockout or modify DNA in animal models to study phenotypes and develop new treatments.

  • Custom RNAi Mouse Models

    RNAi-mediated gene silencing makes complex genetic modifications easier to achieve more quickly and efficiently than traditional knockout technologies. The estimated timeline from project initiation to the generation of ES cell-derived RNAi mice is an estimated 24 – 30 weeks.

  • ES Cell Mutagenesis in Mice

    With ES cell technology, our microinjection experts inject custom ES cells directly into blastocysts, effectively bringing your in vitro research models to life.

  • Knockin/Knockout Mice

    With our industry partners, all types of mutations are achievable in knockout and knockout mice. Create knockin and knockout mice to further your study and aid in drug development.

  • Microinjection Services

    Bridge the gap between your in vitro and in vivo mouse models by using ES cell, DNA, and CRISPR microinjections.

  • Random DNA Transgenesis in Mice

    The DNA vector is injected directly into the pronuclei of zygotes, bringing your customer in vitro models to life with founders available in three to four months.

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CRISPR-Cas9 used under licenses to granted and pending US and international patents from The Broad Institute and ERS Genomics Limited.