Overview

ALZET® Osmotic Pumps offer specific advantages over repeated animal dosing by injection or oral gavage, such as:

  • Continuous delivery, eliminating peak and trough fluctuations
  • Test agent effects develop fully and are easily reproduced, which is particularly advantageous for agents with short half-lives
  • Reduction in animal stress that can develop from frequent handling

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Are injections really the best drug delivery method?

black%20and%20white%20mice.jpgDownload our white paper, "Infusion vs. Injection: Considerations for Administering a Drug Compound Across Preclinical Research Areas," to find out.

Charles River is the exclusive distributor of ALZET® Osmotic Pumps for Austria, Belgium, Czech Republic, France, Germany, Hungary, Ireland, Italy, Luxembourg, Netherlands, Portugal, Spain, Switzerland and UK.

In North America and Europe, Charles River can implant ALZET® Osmotic Pumps as well as other telemetry devices as part of our surgery services.

  • BY STUDY DESIGN

    There are 12 models of ALZET® Osmotic Pumps in 3 physical sizes, and a variety of release rates and durations*. Dosage variability can be achieved by modifying agent concentration; duration can be extended by serial implantation of the pumps.

    Pump Model

    Volume

    Duration

    Release Rate

    1003D

    100 µl 

    3 days 

    1.0 µl/hr

    1007D

    100 µl

    1 week

    0.5 µl/hr

    1002

    100 µl

    2 weeks

    0.25 µl/hr

    1004

    100 µl

    4 weeks

    0.11 µl/hr

    2001D

    200 µl

    1 day

    8.0 µl/hr

    2001

    200 µl

    1 week

    1.0 µl/hr

    2002

    200 µl

    2 weeks

    0.5 µl/hr

    2004

    200 µl

    4 weeks

    0.25 µl/hr

    2006

    200 µl

    6 weeks

    0.15 µl/hr

    2ML1

    2 ml

    1 week

    10 µl/hr

    2ML2

    2 ml

    2 weeks

    5.0 µl/hr

    2ML4

    2 ml

    4 weeks

    2.5 µl/hr

    * Lot Specific Performance Data: The nominal performance is a target for all pumps manufactured. Individual lots of pumps may vary from this target within limits. The actual pumping rate and fill volume of a particular lot (derived by statistical testing) are listed on the top of the instruction sheet included with the pumps.

  • BY ANIMAL & DELIVERY METHOD

    The minimum animal size estimates for Implantation of ALZET® Osmotic Pumps are based on experience with male Sprague Dawley rats and Swiss Webster mice. When using the pumps with other strains or genders, these guidelines should be modified accordingly.

    Pump Model

    Mice SC

    Mice IP

    Rats SC

    Rats IP

    1003D

    10 g

    20 g

    10 g

    20 g

    1007D

    10 g

    20 g

    10 g

    20 g

    1002

    10 g

    20 g

    10 g

    20 g

    1004

    10 g

    20 g

    10 g

    20 g

    2001D

    10 g

    20 g

    10 g

    20 g

    2001

    10 g

    20 g

    10 g

    20 g

    2002

    20 g

    N/A

    20 g

    150 g

    2004

    20 g

    N/A

    20 g

    150 g

    2006

    20 g

    N/A

    20 g

    150 g

    2ML1

    N/A

    N/A

    150 g

    300 g

    2ML2

    N/A

    N/A

    150 g

    300 g

    2ML4

    N/A

    N/A

    150 g

    300 g

    SC = subcutaneous; IP = intraperitoneal

  • VIDEOS

    Watch this overview video to learn more about the technology, benefits, and applications of ALZET® Osmotic Pumps.

    Further videos, including one that describes surgical implantation techniques, can be accessed through our secure portal, The Source℠:

To learn more about ALZET® Osmotic Pumps, visit www.alzet.com.

ALZET® is a registered trademark of DURECT Corporation.

 

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