Biotransformation describes the conversion of a compound to a metabolite through the action of enzymes. Charles River offers a comprehensive service for the isolation, analysis, and identification of metabolites in biological matrices in support of drug safety studies. This service can be provided as part of a full ADME package or as a stand-alone study.

Additionally, a synthetic chemistry service is available to undertake synthesis of metabolites, reference standards, and internal standards to assist with method development and metabolite identification.

Technical Capabilities

  • Radiometric profiling
  • LC-MS and LC-MS/MS
  • GC-MS and ion trap MS
  • CE for oligonucleotides
  • TOF, MALDI-TOF, LTQ Orbitrap, and ion mobility
  • Organic chemistry metabolite synthesis