Preclinical Imaging & Radiochemistry

Molecular imaging is an established technology combining both functional and structural imaging to allow for evaluation of specific in vivo processes in relation to spatial orientation within the model of interest. The unique characteristics of molecular imaging provide investigators with an early stage solution to evaluate critical principles of new entity development: exposure at the target site, binding to the target of interest, and expression of the desired pharmacology. Incorporation of molecular imaging solutions into new entity development programs allows you to rapidly assess results and make essential decisions earlier in the drug development process. Imaging can be used in many development efforts, such as those targeting insight into disease processes, validity of new therapeutic targets, target/non-target organ interaction, mechanism of action, biodistribution and others.

Our comprehensive preclinical imaging, radiochemistry, and data analysis solutions include:

  • ANIMAL MODEL IMAGING MODALITIES
    • MicroPET (positron emission tomography)
    • MicroSPECT (single photon emission computed tomography)
    • Large and small animal (computed tomography)
    • Quantitative whole-body autoradiography (QWBA), long- and short-lived isotopes 
      • Two-dimensional, GLP-compliant
      • Three-dimensional
  • RADIOCHEMISTRY SERVICES
    • Radiolabeling of cellular therapeutics
    • Radiolabeling of antibodies, peptides, oligonucleotide, nanoparticles, and small molecules
    • Tracers for translational imaging
    • SPECT for mouse 
      • Large molecules: 125I, 123I, 111In, 99mTc
      • Small molecules: 125I, 123I
    • PET tracers for large animals
      • Large molecules: 124I, 89Zr, 11C, 18F
      • Small molecules: 124I, 11C, 18F
    • Chemistry: organic and radiochemical to label any drug or tracer
    • Regulatory support: current ANDAs, INDs, DMFs; clinical trials
    • Our cyclotron produces 11C,13N,18F, 124I, 89Zr
  • DATA ANALYSIS & INTERPRETATION

    Our scientists provide analysis of imaging datasets in real-time, allowing streamlined workflow with application-specific tools. Key features include:

    • Powerful visualization of complex data and trends
    • Manual, semi-automatic, or automatic tools to export return on investment values into spreadsheet formats
    • Various threshold methods applied to individual, multi-modal, and dynamic datasets
    • Batch processing with customizable analysis routines for fast, quantitative assessments
    • Reliable quantification of distribution of radiopharmaceuticals, biologics, and small molecules in whole-body, organ, and sub-organ regions
    • Multi-disciplinary integration of in vitro/ex vivo characterization and in vivo imaging for a better understanding of distribution, kinetics, and targeting
    • Kinetic modeling
    • Automated processes for organ segmentation
    • Availability of brain atlases for rodents and large animals
  • ADDITIONAL IMAGING MODALITIES
    • Dedicated cyclotron
    • All major in vivo imaging modalities for large and small animal 
      • SPECT
      • PET
      • MRI
      • CT
      • DEXA
      • Fluoroscopy
      • X-ray
      • Laser doppler
      • Ultrasonography
    • Complementary assays 
      • In vivo imaging
      • Ex vivo biodistribution
      • Animal model development
      • Histology
    • Quantitative autoradiography 
      • Long- and short-lived radioisotopes
      • Two-dimensional, GLP-compliant
      • Three-dimensional