Transmission & Scanning Electron Microscopy (TEM & SEM)
Recognized for our experience in this field, Charles River offers full-service GLP ultrastructural microscopy evaluations with both transmission (TEM) and scanning (SEM) electron microscopic capabilities.
Check out our poster presentations from the Society of Toxicology's 2018 annual meeting.
Ultrastructural morphology procedures enable the visualization of unique details of the structure and the quantification of cellular organelles. This imaging technique gives investigators precise data on mitochondria, peroxisomes, smooth and rough endoplasmic reticulum, Golgi cytoskeletal components, cytoplasmic granules, and inclusion bodies, which assist in determining a compound’s mode of action and understanding the pathogenesis of toxicologically-related lesions. SEM enables the investigator to examine the surface topography and morphology of cells, tissues or medical devices by scanning a beam of electrons across a sample. This imaging technique may also be employed in studies in which exterior damage or integrity is of concern.
- Ultrastructural pathology
- Quantification of peroxisomes
- Viral particle identification, characterization and tabulation
- Cell culture contamination identification
- Evaluation of tissue/medical device interface
- Characterization of red blood cell morphology
- Transmission electron microscopy (TEM)
- Scanning electron microscopy (SEM)
- Light microscopy
- Dual-energy X-ray absorptiometry (DXA)
- Quantitative computed tomography (QCT)
- Micro-computed tomography (Micro-CT)
- Digital radiography