Molecular Pathology Services

In drug discovery and preclinical safety assessment, morphological changes in cells are often accompanied by alterations in DNA, RNA, or protein molecules. A further understanding of these molecular changes can help to understand target distribution and pharmacology as well as the elucidation of mechanism(s) of toxicity and/or efficacy. 

Our team combines a strong history in molecular biology and histopathology to relate gene expression to tissue histomorphology in both normal tissues and therapeutic models of disease, providing you with valuable functional genomics information. This results in the best possible interpretation and troubleshooting of molecular-based tools, such as chromogenic in situ hybridization (CISH), fluorescent in situ hybridization (FISH), and real-time quantitative polymerase chain reaction (qPCR) as applied to toxicological pathology issues.

Our services include:

  • Procurement, embedding and sectioning of study tissues
  • Synthesis of DNA and RNA probes (isotopic and non-isotopic)
  • Optimized hybridization
  • Histological evaluation by board-certified pathologists
  • Reporting with representative color photomicrographs