Overview
Rats and mice are the rodent species routinely used because of their susceptibility to toxic challenge, tumor induction, and carcinogenicity. In addition, we have a vast amount of background information available on their survival, physiology, pathology and susceptibility to different test items. The rabbit is a particularly useful animal model for assessing ocular and dermal irritation and is also the primary nonrodent species for developmental toxicity studies.
Rabbit Housing Facility in Edinburgh
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ROUTES OF ADMINISTRATION
- Oral: gavage, capsule, diet
- Dermal
- Intraocular/intravitreal
- Intramuscular
- Inhalation
- Intranasal
- Infusion
- Intravenous
- Intraperitoneal
- Penile/vaginal
- Rectal
- Other nonstandard routes by discussion
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STUDY DESIGNS
- Acute
- Subchronic
- Chronic
- Developmental and reproductive
- Juvenile
- Carcinogenicity