Acute and Chronic Surgical Models 

Charles River offers a range of acute and chronic surgical models for use in any drug metabolism, pharmacology, or safety study type. Our research surgeons have extensive experience in the development of sophisticated surgical procedures in a variety of rodent and large animal species and are available to assist in the creation of the most relevant animal model for an enhanced understanding of your compound.

Surgical Capabilities

  • STUDY DESIGN
    • Proof-of-concept/Mechanism of action
    • Safety and biodistribution
    • Tumorigenicity
    • Acute chronic toxicity
    • Targeted delivery
  • THERAPIES
    • Small molecule
    • Large molecule
    • Cell therapies
    • Gene therapies
    • Medical device
    • Combination products
  • ROUTES OF ADMINISTRATION
    • Intrathecal/epidural
    • Intraparenchymal – brain and spinal cord
    • Intracerebroventricular (ICV)
    • Localized peripheral nerve
    • Epicardial
    • Endocardial
    • Cardiac antegrade and retrograde 
    • Intra-aortic
    • Peripheral vascular – arterial and venous  
    • Intrahepatic
    • Intra-articular
    • Direct cartilage and tendon
    • Long bone, spinal and cranio-facial implant
    • Direct intestinal
    • Intravesicular (bladder)
    • Retrograde renal
    • Organ-specific
    • Intraprostatic

Surgical Models

  • NEUROLOGICAL MODELS
    • Spinal cord contusion
    • Intrathecal device implantation
    • Epidural device implantation
    • Intracranial device implantation
    • Stereotaxic administration
    • Stroke
    • Parkinson’s disease
  • ORTHOPAEDIC MODELS
    • Joint/cartilage
    • Trauma – bone fracture/defect repair
    • Spinal fusion and spinal instability/fixation
    • Disc degeneration
    • Craniofacial
    • Dental
    • Osteonecrosis
  • RENAL MODELS
    • Aminoglycoside nephrotoxicity
    • Renal ischemia-reperfusion injury
    • Renal transplantation
    • Partial nephrectomy for evaluating hemostasis
  • WOUND HEALING MODELS
    • Full thickness excision
    • Split thickness wound created with dermatome
    • Full thickness incision
    • Burn wounds
    • Bacterial infection (up to BSL2)
    • Necrotic debridement 
    • Scar formation
  • CARDIOVASCULAR MODELS
    • Acute myocardial infarction
    • Congestive heart failure
    • Chronic cardiac and peripheral ischemia
    • Peripheral arterial disease
    • Goldblatt hypertension
    • Aortic banding
    • Coronary artery bypass
    • ECMO devices
  • SUPPORT SERVICES
    • Telemetry implantation
    • Arterial and venous catheterization
    • Targeted delivery
    • Anesthesia support
    • Intrathecal and epidural catheterization