DART Studies

Charles River offers overall developmental and reproductive toxicology (DART) program planning and individual study design to conduct safety assessments for your products according to internationally recognized guidelines, including ICH and OECD.


Three white mice.

Developmental and Reproductive Toxicity Testing in the 21st Century

This four-part webinar series discusses updated information on study designs for rodents, rabbits, NHPs, dogs, and minipigs in DART testing.
Watch the Webinars


We conduct male and female fertility, developmental toxicity (embryo-fetal development), pre- and postnatal development and multigenerational studies, (including OECD 443, the Extended One Generation Reproductive Toxicity Study, (EOGRTS)), to assess the potential effects of novel products on the entire reproductive spectrum. Our expertise includes pharmaceuticals (including vaccines, biopharmaceuticals, and veterinary and medical devices) agrochemicals, industrial chemicals and food additives. 


White mouse

Is Sodium Molybdate Dihydrate Reprotoxic?

We collaborated with the International Molybdenum Association on an OECD 416 study, assessing the potential of sodium molybdate dihydrate to induce reproductive toxicity in male and female Sprague Dawley rats.
Download the White Paper


A full range of rodent and nonrodent species are tested with dose routes ranging from dermal to intravenous infusion. A range of specialized functional evaluations is also available, including neurobehavioral testing and immunologic assays. All studies are supported by our own laboratory and regulatory experts.

Virtual attendees at American College of Toxicology (ACT) Annual Meeting.

American College of Toxicology (ACT) Annual Meeting Resources

Although this year’s ACT Annual Meeting was virtual, our experts presented several continuing education sessions, symposiums, exhibitor sessions, and posters throughout the week. Explore our resources to download presentations, poster recordings, and other content. Download Now


Congratulations to Dr. Alan Hoberman for being the 2021 recipient of the ‘Scientific Achievement Award’ by the Reproductive and Developmental Toxicology Specialty Section (RDTSS) of Society of Toxicology.

This annual award is presented to an RDTSS member for lifetime achievements and contribution of a particularly influential body of work to the field of reproductive and developmental toxicology. Additional criteria for evaluation include leadership service, impact, and mentorship. The awardee is selected from among membership nominations by a committee formed by the RDTSS Executive Committee.