Overview

Charles River provides a full range of toxicity-based study types to assess the environmental risk of pharmaceutical, biopharmaceutical, food additive, chemical, biocide, and agrochemical products. We have experience conducting studies in a variety of test articles, including those that are volatile, unstable or partially soluble. We offer studies to assess the toxicity of test articles to a range of species, including:

  • Avian
  • Waste-water bacteria
  • Algae, aquatic and terrestrial plants
  • Daphnia and fish
  • Soil microorganisms
  • Freshwater and marine species

We also provide a full analytical service for the method validation and routine analysis required in support of many of the aquatic studies.

Plant & Aquatic Species

  • Activated sludge respiration inhibition (OECD 209)
  • Algal growth inhibition (freshwater and marine) (OECD 201)
  • Acute and prolonged toxicity to Daphnia magna (OECD 202, OECD 211)
  • Acute (96-hour) and prolonged toxicity to cold- and warm-water fish (e.g., rainbow trout, bluegill sunfish, carp, fathead minnow, zebrafish) (OECD 203)
  • Fish embryo toxicity test (FET test) (OECD 236)
  • Fish, toxicity test on egg and sac-fry stage (OECD 212)
  • Fish early life stage (OECD 210)
  • Radiolabeled (or cold) bioaccumulation and/or metabolism in fish (OECD 305)
  • Lemna spp. growth inhibition (OECD 221)
  • Acute and prolonged sediment water toxicity test to Chironomus riparius (OECD 235, OECD 218, OECD 219)
  • Sediment-water toxicity test with Lumbriculus (OECD 225)

Other Species

  • Acute and reproduction toxicity to earthworms (OECD 2017, OECD 222)
  • Collembolan reproduction in soil (Folsomia candida) (OECD 232)
  • Plants, seedling emergence and growth (OECD 208)
  • Beneficial arthropods
  • Effects on soil microbial activity, carbon mineralization and nitrogen transformation

Biodegradation

  • Ready biodegradation tests (e.g. OECD 301 B/D/F, OECD 310)
  • Inherent biodegradation tests (e.g. OECD 302/B)
  • Simulation tests (e.g. OECD 303/A)