Endocrine Disruptor Testing Services
With current EPA endocrine disruptor regulations, proper testing is more important than ever.
Whether you require Tier I or Tier II tests, our experts can help at every stage, from initial data gathering through evaluation and interpretation for hazard/risk assessment. All studies are validated and performed according to GLP principles.
Overview of assays for endocrine disruption as proposed by EPA and OECD:
|Estrogen receptor (ER) binding – rat uterine cytosol||890.1250|
|Estrogen receptor (hERa) binding – human recombinant||493|
|Estrogen receptor – (hERα) transcriptional activation – human cell line (HeLa-9903)||890.1300||455|
|Androgen receptor (AR) binding – rat prostate cytosol||890.1150|
|Androgen receptor (AR) – transcriptional activation – CHO-K1 cell line (AR-EcoScreen™)||458|
|Steroidogenesis – human cell line (H295R)||890.1550||456|
|Aromatase (human recombinant) assay||890.1200|
|Uterotrophic assay (rat)||890.1600||440|
|Pubertal female (rat)||890.1450|
|Pubertal male (rat)||890.1500|
|Amphibian metamorphosis (frog)||890.1100||231|
|Fish short-term reproduction||890.1350||229|