Endocrine Disruptor Testing Services

With current EPA endocrine disruptor regulations, proper testing is more important than ever.

Whether you require Tier I or Tier II tests, our experts can help at every stage, from initial data gathering through evaluation and interpretation for hazard/risk assessment. All studies are validated and performed according to GLP principles.

Overview of assays for endocrine disruption as proposed by EPA and OECD:

In Vitro OPPTS
Guideline
OECD
Guideline
Estrogen receptor (ER) binding – rat uterine cytosol 890.1250  
Estrogen receptor (hERa) binding – human recombinant   493
Estrogen receptor – (hERα) transcriptional activation – human cell line (HeLa-9903) 890.1300 455
Androgen receptor (AR) binding – rat prostate cytosol 890.1150  
Androgen receptor (AR) – transcriptional activation – CHO-K1 cell line (AR-EcoScreen™)   458
Steroidogenesis – human cell line (H295R) 890.1550 456
Aromatase (human recombinant) assay 890.1200  
In Vivo OPPTS
Guideline
OECD
Guideline
Uterotrophic assay (rat) 890.1600 440
Hershberger (rat) 890.1400 441
Pubertal female (rat) 890.1450  
Pubertal male (rat) 890.1500  
Amphibian metamorphosis (frog) 890.1100 231
Fish short-term reproduction 890.1350 229