Environmental Fate Testing

Charles River can support the eFate testing needs of your pharmaceutical, biopharmaceutical, chemical, agrochemical, biocide or food additive development program in our modern, open-plan, flexible laboratories using soils, sediments and natural waters sourced from sites worldwide. The viability (biomass) of each test system is verified (if applicable) prior to study initiation.

We perform the in-life phases of environmental fate studies in environmentally controlled incubation rooms or incubators. Self-contained flow-through incubation systems (aerobic and anaerobic), with the flexibility to accommodate different trapping systems for collection of volatile products, are available for radiolabeled degradation studies; a similar flow-through apparatus is used in photolysis studies. Sealed systems are available for investigations with volatile test items, as well as systems for collection and quantification of reduced radiolabeled volatile products.

We can obtain test systems such as sediment, surface waters and soils from a variety of local and international geographical sources. Prior to study conduct, we fully characterize all test systems and confirm their viability.

eFate Studies

  • Aerobic and anaerobic degradation in soil and aquatic sediment systems
  • Mineralization in surface water
  • Soil adsorption-desorption/mobility
  • Hydrolytic stability
  • Photolytic stability (soil and aqueous)
  • Sludge adsorption/desorption
  • Radiolabeled or nonradiolabeled