Carcinogenicity Testing in rasH2 Transgenic Mice

The rasH2, p53+/- and Tg.AC models are three primary transgenic mouse models that were initially accepted by regulatory agencies as the result of a multinational effort by The International Life Sciences Institute/Health and Environmental Sciences Institute’s Alternatives to Carcinogenicity Testing Project in conjunction with the directives of ICH S1B, from 1996 to 2001. Since then, the rasH2 model has become the model of choice most often used as a replacement for a traditional 2-year mouse carcinogenicity study.

Charles River offers the transgenic rasH2 mouse model as an alternative to the full 2-year carcinogenicity study design and has commenced more than 60 studies in this model since 2013.

For more information on transgenic mouse and rat model creation, click here