Neurotoxicity Testing

We understand how important it is to know if your test material of interest adversely affects the chemistry, structure, or function of the nervous system. With this need in mind, the neurotoxicology program at Charles River encompasses a broad range of products, including pharmaceuticals, biopharmaceuticals, biologics, and chemicals in both rodent and nonrodent species. With over two decades of experience, we have valuable historical control databases.

Charles River has a knowledgeable staff of scientists and technical personnel who routinely perform neurotoxicity screening tests for possible on- or off-target effects, specialized target tissue delivery, expanded investigative studies, and developmental neurotoxicity, and any preclinical study that requires the analysis of abuse and dependence liability potential.

Capabilities

  • Neurobehavior, including assays of locomotor activity, rotarod forced activity, water maze learning and memory testing, auditory startle habituation, and functional observational batteries
  • Abuse liability testing with any drug that crosses the blood-brain barrier regardless of therapeutic indication
  • Ototoxicity testing, GLP-compliant and measuring auditory function, cytocochleogram, otic histology, and evaluation of potential recovery
  • Neurochemistry, including cholinesterase assays in red blood cell, plasma, and brain samples, as well as quantification of endogenous levels of neurotransmitters
  • Neuropathology, including in situ perfusion, morphometry, stereology, and qualitative neuropathological evaluations
  • STUDY DESIGNS
    • Acute neurotoxicity
    • Subchronic neurotoxicity
    • Developmental neurotoxicity
    • Behavioral developmental toxicity
    • Safety pharmacology
    • NMDA receptor antagonist
  • DOSE ROUTES
    • Standard dose routes
    • Routine and specialized routes of parenteral injection or infusion and target-tissue administration
      • Intracisternal
      • Intracerebral
      • Intracerebroventricular
      • Intrathecal
      • Epidural
      • Subcutaneous
      • Intravenous
Pharmaceutical Formulation Development

Scientists working in pharmaceutical formulation laboratory designed to eliminate cross-contamination and suitable for the preparation of preclinical dosing formulations of any batch sizeDon’t let your formulation delay your GLP toxicology studies. The formulation is essential to the integrity and success of any preclinical program, but the one used in efficacy studies may not be suitable for a safety program.

 

Learn more about our formulation development capabilities