Neurotoxicity Testing

We understand how important it is to know if your test material of interest adversely affects the chemistry, structure, or function of the nervous system. With this need in mind, the neurotoxicology program at Charles River encompasses a broad range of products, including pharmaceuticals, biopharmaceuticals, and chemicals in both rodent and nonrodent species. With over two decades of experience, we have valuable historical control databases.

SOT 2018 Posters

Toxicologist with vialsCheck out our poster presentations from the Society of Toxicology's 2018 annual meeting.

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Charles River has a knowledgeable staff of scientists and technical personnel who routinely perform neurotoxicity screening tests for possible on- or off-target effects, specialized target tissue delivery, expanded investigative studies, and developmental neurotoxicity.

CAPABILITIES

  • Neurobehavior, including assays of locomotor activity, rotarod forced activity, water maze learning and memory testing, auditory startle habituation, and functional observational batteries
  • Neurochemistry, including cholinesterase assays in red blood cell, plasma, and brain samples, as well as quantification of endogenous levels of neurotransmitters
  • Neuropathology, including in situ perfusion, morphometry, stereology, and qualitative neuropathological evaluations
  • STUDY DESIGNS
    • Acute neurotoxicity
    • Subchronic neurotoxicity
    • Developmental neurotoxicity
    • Behavioral developmental toxicity
    • Safety pharmacology
    • NMDA receptor antagonist
  • DOSE ROUTES
    • Standard dose routes
    • Routine and specialized routes of parenteral injection or infusion and target-tissue administration
      • Intracisternal
      • Intracerebral
      • Intracerebroventricular
      • Intrathecal
      • Epidural
      • Subcutaneous
      • Intravenous