Overview

Charles River performs safety and efficacy assessments for all ocular indications. Ocular effects of compounds administered by other routes, such as oral, can also be characterized. These studies can be conducted under GLP or non-GLP conditions, either as stand-alone studies or as part of general and specialty toxicology programs. Non-GLP pilot or proof-of-concept studies, as well as in vitro ocular irritancy evaluations are also available for your early research.

Experience

  • Species
    • Rodent
    • Nonrodent
  • Compound Classes
    • Small molecule
    • Biologics
    • Cell therapy
    • Gene therapy
    • Implants/transplants

Support Services

  • Specular microscopy for noninvasive, in vivo evaluation of the corneal endothelium
  • Electroretinography
  • Spectral domain optical coherence tomography (SD-OCT, anterior and posterior)
  • Tonometry (IOP) evaluations
  • Pachymetry (corneal thickness)
  • Digital fundus photography/video
  • Confocal scanning laser ophthalmoscope (multiple image modes - infrared and tomography for 3D images)
  • Fundus autofluorescence
  • Fluorescein angiography (FA) and Indocyanine green angiography (ICG)
  • Vitrectomy
  • Quantitative autoradiography
  • Ocular and systemic tissue distribution
  • Enhanced microscopic evaluation
  • Ocular surgery/implant