Ocular Toxicity Studies

Charles River performs safety and efficacy assessments for all ocular indications. Ocular effects of compounds administered by other routes, such as oral, can also be characterized. These studies can be conducted under GLP or non-GLP conditions, either as stand-alone studies or as part of general and specialty toxicology programs. Non-GLP pilot or proof-of-concept studies, as well as in vitro ocular irritancy evaluations are also available for your early research. Our on-site ACVO board-certified veterinary ophthalmologists have experience with both rodents and nonrodents using small molecule, biologics, cell therapy, gene therapy, implants, and transplants.

Dosing Routes

  • Intravitreal 
  • Intracameral 
  • Subconjunctival/tenons 
  • Subretinal
  • Topical 
  • Systemic

Ocular Evaluations

  • Specular microscopy for noninvasive, in vivo evaluation of the corneal endothelium
  • Tonometry (IOP) evaluations
  • Enhanced microscopic evaluation
  • Ocular histopathology
  • Quantitative autoradiography (2D and 3D)
  • Ocular and systemic tissue distribution (detailed ocular tissue dissections; radioisotope-labeled, LC-MS/MS, ELISA, PET, SPECT)
  • Corneal fluorescein staining
  • Schirmer tear/phenol red thread testing

Ocular Preclinical Examinations & Services

  • Electroretinography (ISCEV, custom protocols, and VEP)
  • Spectral domain optical coherence tomography (SD-OCT; anterior and posterior) and retinal layer segmentation
  • Pachymetry (corneal thickness)
  • Digital fundus photography/video
  • Confocal scanning laser ophthalmoscopy (CSLO; multiple image modes – infrared and tomography for 3D images)
  • Fundus autofluorescence
  • Fluorescein angiography (FA)
  • Indocyanine green angiography (ICG)
  • Vitrectomy
  • Aqueous/vitreous humor collections and biomarker quantification
  • Slit-lamp biomicroscopy
  • Indirect and direct ophthalmoscopy
  • Gonioscopy
  • Streak retinoscopy

Frequently Asked Questions (FAQs) on Ocular Toxicology