Phototoxicity Testing Services

Charles River established the first GLP-compliant, AAALAC-accredited contract photobiology facility in the industry, which has been meeting our clients’ phototoxicology needs since 1989. We serve the pharmaceutical, chemical and agrochemical industries with in vivo and in vitro study designs that meet standard and specialized requirements for evaluation of any test material.

Our scientists pioneered the quantitative study of cutaneous phototoxicology by designing the instruments, techniques, and protocols now accepted as industry standards for regulatory phototoxicology evaluations. We have used this strong foundation to develop unique and technologically rigorous phototoxicology services in collaboration with our research models experts and highly-skilled pathologists to support our clients’ research.

Utilizing a number of different light sources, including visible light, xenon arc solar simulators, and fluorescent ultraviolet radiation sources, our scientists can design specialized exposure conditions and custom light source configurations for any product. We proudly offer the industry’s only FDA CFR Part 11-compliant radiometry and spectroradiometry systems.

    • Cytotoxicity endpoints in cell lines or hepatocytes
    • In vitro 3T3 NRU phototoxicity assay (OECD 432; ICH S10)
    • In vitro phototoxicity in the human reconstructed skin model Epiderm (ICH S10)
    • Photo Ames assay
    • Melanin Binding assay (ICH S10)
    • In vitro drug screening, development and safety testing
    • Regulatory experience in the phototoxicology field
    • Qualitative and quantitative phototoxicology in mice, rats and guinea pigs
    • Photoallergy studies, including photoactivated sensitizers
    • Safety assessment of photodynamic drugs
    • Safety assessment of unique light sources
    • Expertise in ocular phototoxicity in rats and rabbits
      • Board-certified veterinary ophthalmologists
      • Experienced ophthalmic pathologists
    • Light exposure (UVR, visible, near-infrared) under surgical conditions
    • Assessment of potential damage to thoracic and abdominal organs