Many of Charles River's assays are direct replacements for tests or screenings done on animals, and we have been leading the way in the development, validation, and acceptance of various animal-free models.

Many acute toxicity tests have been, or are being, effectively replaced by in vitro human, animal and 3D tissue alternatives. This shift is particularly evident in skin irritation, skin corrosion and skin sensitization models, all of which are fully supported at Charles River. There are also models to assess, phototoxicity, ocular irritation and severe damage. In addition, we are developing models to tests toxicities and efficacy in other tissues such as the lung, mouth and gut.