In Vitro Toxicity Testing
Many of Charles River's assays are direct replacements for tests or screenings done on animals, and we have been leading the way in the development, validation, and acceptance of various animal-free models.
Comparison of Histopathological and Cell Viability Results from In Vitro Rat and Human Airway™ Models for Translational Inhalation Toxicity Testing (presented at the 2018 AIT Conference)
Many acute toxicity tests have been, or are being, effectively replaced by in vitro human, animal and 3D tissue alternatives. This shift is particularly evident in skin irritation, skin corrosion and skin sensitization models, all of which are fully supported at Charles River. There are also models to assess, phototoxicity, ocular irritation and severe damage. In addition, we are developing models to tests toxicities and efficacy in other tissues such as the lung, mouth and gut.
In Vitro and Alternative Models for Regulatory Submission
Dr. Clive Roper and Dr. Lauren Black were honored to contribute to the American College of Toxicology’s ToxChats© podcast series. In the first chapter of this episode, they discuss the current landscape of in vitro and alternative models and share their thoughts about the future direction of the field. In the second chapter, Dr. Paul Brown, associate director of pharmacology and toxicology at CDER/FDA, discusses the acceptance of in vitro models for safety evaluations and the value of integrative toxicology. Listen Now